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Chapters: Monoclonal Antibodies, Antivenom, Polyclonal Antibodies, Tnf Inhibitor, Human Anti-Mouse Antibody. Source: Wikipedia. Pages: 44. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by one type of immune cell that are all clones of a unique parent cell. Given almost any substance, it is possible to create monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see "Nomenclature of monoclonal antibodies"). The idea of a "magic bullet" was first proposed by Paul Ehrlich, who, at the beginning of the 20th century, postulated that, if a compound could be made that selectively targeted a disease-causing organism, then a toxin for that organism could be delivered along with the agent of selectivity. In the 1970s, the B-cell cancer multiple myeloma was known, and it was understood that these cancerous B-cells all produce a single type of antibody (a paraprotein). This was used to study the structure of antibodies, but it was not yet possible to produce identical antibodies specific to a given antigen. Production of monoclonal antibodies involving humanmouse hybrid cells was described by Jerrold Schwaber in 1973 and remains widely cited among those using human-derived hybridomas, but claims to priority have been controversial. A science history paper on the subject gave some credit to Schwaber for inventing a technique that was widely cited, but stopped short of suggesting that he had been cheated. The invention was conceived by Prof. Pieczenik, with Prof. John Sedat, Elizabeth...More: http://booksllc.net/?id=315043
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Therapeutic Antibodies: Monoclonal Antibodies, Antivenom, Polyclonal Antibodies, Tnf Inhibitor, Human Anti-Mouse Antibody
Book reviews » Therapeutic Antibodies: Monoclonal Antibodies, Antivenom, Polyclonal Antibodies, Tnf Inhibitor, Human Anti-Mouse Antibody
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